Doug Cole joined Flagship Pioneering in 2001, and he focuses on life science investments. He came to Flagship with significant industry experience and a strong academic background. Doug holds an A.B. magna cum laude with High Distinction in English from Dartmouth College, where he was a senior fellow and a member of Phi Beta Kappa, and an M.D. from the University of Pennsylvania School of Medicine, where he was a member of Alpha Omega Alpha. He obtained post-graduate training in medicine at the Johns Hopkins Hospital in Baltimore, MD and in neurology at the Massachusetts General Hospital in Boston, MA. In 1992, Doug was appointed instructor in neurology at Harvard Medical School and an assistant in neurology at the Massachusetts General Hospital. He established a research program investigating the mechanistic basis of neuronal signaling events and plasticity in neuro-psychiatric disorders with the support of the NIH and several non-profit research foundations.
In 1996, Doug joined Cytotherapeutics, in Providence, RI. As medical director, he oversaw various research and clinical activities related to the company’s cell-based therapeutic technologies. In 1997, he was appointed program executive at Vertex Pharmaceuticals, Inc., in Cambridge, MA, where he led a multidisciplinary program that conducted preclinical development through Phase II studies in tissue protection and repair, oversaw an international research collaboration, and was responsible for identifying strategic market and technology opportunities in multiple arenas.
At Flagship, Doug has led investments in Agios Pharmaceuticals (NASDAQ:AGIO), Alvine Pharmaceuticals, Avedro, CombinatoRx (NASDAQ:ZLCS), Concert Pharmaceuticals (NASDAQ:CNCE), Editas, Quanterix Corporation, Receptos (NASDAQ:RCPT), Seventh Sense Biosystems, and Tetraphase Pharmaceuticals (NASDAQ:TTPH). He is a co-founder of Flagship portfolio companies Ensemble Therapeutics, Permeon Biologics, Moderna Therapeutics, and Syros Pharmaceuticals. He currently serves on the board of directors of Agios, Editas Medicine, Foghorn, Denali Therapeutics, Quanterix and TORQUE. He formerly served on the board of directors of Avedro, AVEO Pharmaceuticals (NASDAQ: AVEO), CombinatoRx, Concert, CGI, Moderna, Morphotek, Receptos, Resolvyx, Selecta, Seventh Sense and Tetraphase.
Doug is a member of the scientific advisory board and the board of directors of the Spinal Muscular Atrophy Foundation.